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Medchemexpress LLC Arn-21934 | 2230854-93-8 | 98.1% | 360.46 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY137466100MG

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ARN-21934 is a potent, highly selective, and blood-brain barrier (BBB) penetrant inhibitor specifically targeting human topoisomerase II α over β. It inhibits DNA relaxation with an IC50 of 2 μM, making it significantly more potent than the anticancer agent Etoposide. ARN-21934 demonstrates a favorable in vivo pharmacokinetic profile and is considered a promising lead compound for anticancer research.

  • High potency and selectivity: Potently and selectively inhibits human topoisomerase II α.
  • Blood-brain barrier penetrant: Able to cross the blood-brain barrier.
  • Favorable pharmacokinetic profile: Exhibits good clearance values and a half-life of 149 minutes in circulation.
  • Anticancer potential: Shows antiproliferation activity against various human cancer cell lines.

Catalog No. 50-003-51755


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