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Medchemexpress LLC ARS-1323 | 1698024-73-5 | 430.84 | 25 MG
Supplier: Medchemexpress LLC 25MGHYU00416
ARS-1323 is a KRAS G12C inhibitor that specifically binds to the cysteine residue on the mutant K-Ras protein. This action locks K-Ras in its GDP-bound conformation, blocking activation and downstream signaling pathways. It is suitable for investigating signal transduction mechanisms and growth characteristics in tumor cells driven by K-Ras G12C.
- Inhibits KRAS G12C
- Blocks K-Ras activation and downstream signaling
- Investigates signal transduction mechanisms and growth characteristics
- Reduces uptake of [18F]PFPMD by KRAS G12C-mutant H358 NSCLC cells
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