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Medchemexpress LLC ARS-1630 | 1698055-86-5 | 430.84 | 25 MG
Supplier: Medchemexpress LLC 25MGHYU00417
ARS-1630 is a novel inhibitor of mutant K-ras G12C, derived from patent WO 2015054572 A1. It is characterized as a less active enantiomer of ARS-1620. This compound targets mutant K-ras G12C, which is considered potentially druggable through allele-specific covalent targeting of Cys-12 near an inducible allosteric switch II pocket. This approach relies on the active cycling of KRAS G12C between its active-GTP and inactive-GDP conformations, as the accessibility of the switch II pocket is limited to the GDP-bound state.
- Specifically inhibits mutant K-ras G12C.
- It is a less active enantiomer of ARS-1620.
- Molecular weight: 430.84.
- Chemical formula: C21H17ClF2N4O2.
- Appears as a white to yellow solid.
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