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Medchemexpress LLC Ars-853 | 1629268-00-3 | 98.39% | 432.94 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1970610MM/1ML

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ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

  • Cell-active, selective, covalent KRAS G12C inhibitor.
  • IC50 of 2.5 μM for KRAS(G12C).
  • Inhibits mutant KRAS-driven signaling.
  • Reduces GTP-bound KRAS levels by more than 95% at 10 μM in KRASG12C-mutant lung cancer cells.
  • Inhibits proliferation with an IC50 similar to its target inhibition IC50.
  • Selectively reduces KRAS-GTP levels and RAS-effector signaling in KRASG12C-mutant cells.
  • Induces apoptosis in four KRASG12C mutant cell lines.

Catalog No. 50-004-02750


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