Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC ARS-853 | 1629268-00-3 | 98.39% | 432.94 | 25 MG
Supplier: Medchemexpress LLC 25MGHY19706
ARS-853 is a cell-active, selective, and covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation.
- Selective KRAS G12C inhibition: designed to bind to KRASG12C with high affinity.
- Potent cellular activity: reduces GTP-bound KRAS levels by over 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Antiproliferative effects: inhibits proliferation in KRASG12C mutant lung cancer cell lines with an IC50 of 2.5 μM.
- Induces apoptosis in four KRASG12C mutant cell lines.
- Suppresses effector signaling: completely suppresses the effects of exogenous KRASG12C expression on KRAS-GTP levels, KRAS-BRAF interaction, and ERK signaling.
- Intended for research use only.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?