Cayman Chemical ARUK3001185 10mg

Supplier:  Cayman Chemical 3711310 MG

An inhibitor of NOTUM (IC50 = 6.7 nM); selective for NOTUM over a panel of 39 serine hydrolases and 485 kinases, including CK1 and GSK3, at 10 µM and a panel of 47 receptors, ion channels, transporters, and enzymes at 30 µM, but does inhibit 5-HT3A, α4β2 subunit-containing nAChRs, and MAO-A (IC50s = 4.5, 10, and 28 µM, respectively); prevents NOTUM-induced decreases in Wnt3a signaling in a cell-based reporter assay (EC50 = 110 nM)

Catalog No. 50-291-5164