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Medchemexpress LLC HY-138642 10mg , ARV-471 CAS:2229711-68-4 Purity:>98%
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Supplier:  Medchemexpress LLC HY13864210MG

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HY-138642 10mg ARV-471 CAS: 2229711-68-4 ARV-471 is an oral estrogen receptor PROTAC protein degrader for breast cancer. ARV-471 is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. ARV-471 leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. ARV-471 robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of ~2 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

Catalog No. 50-225-9509


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