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Apexbio Technology LLC AS-605240 648450-29-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A51765.1
AS-605240 (CAS 648450-29-7) is a cell-permeable small molecule inhibitor selectively targeting class I phosphoinositide 3-kinases (PI3Ks) with pronounced potency against the PI3K isoform (IC50 0 008 M) and lower activity for PI3K / / (IC50 0 06 0 27 and 0 3 M respectively) Structural studies show that AS-605240 binds to PI3K via interactions with Lys-833 and Val-882 It impairs PI3K/Akt signaling as evidenced by inhibition of C5a-induced PKB phosphorylation in RAW264 macrophages In vivo AS-605240 reduces leukocyte migration and suppresses joint inflammation in mouse models of peritonitis and collagen-induced arthritis highlighting its value for investigating PI3K -mediated immune pathways and inflammatory processes
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