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Medchemexpress LLC AS-99 TFA | 99.2% | C29H31F6N5O5S2 | 50 MG
Supplier: Medchemexpress LLC HY141429A50MG
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor with anti-leukemic activity. It blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces leukemia burden in vivo. The compound exhibits over 100-fold selectivity towards ASH1L, showing no significant inhibition on a panel of 20 other histone methyltransferases at 50 μM.
- Potent and selective ASH1L histone methyltransferase inhibitor
- Blocks cell proliferation and induces apoptosis
- Downregulates MLL fusion target genes
- Reduces leukemia burden in vivo
- Exhibits over 100-fold selectivity towards ASH1L
- Favorable exposure in plasma with a half-life of approximately 5-6 hours
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