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Cayman Chemical AsIaloglycoproteIn RECPTR 1
Supplier: Cayman Chemical 38095100 UL
A p300 and CBP inhibitor binds to the p300 and CBP bromodomains (Kds 167 and 151 nM respectively) selective for p300 and CBP over BRD4 as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 UM displaces acetylated histones from CBP in a cell-free assay (IC50 170 nM) reduces colony formation and increases differentiation of primary murine leukemic blasts and delays disease initiation following leukemic blast transplantation into sub-lethally irradiated mice when used at concentrations of 5 and 10 UM
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