Medchemexpress LLC Ask1-in-2 | 2541792-70-3 | 99.6% | 364.38 g·mol⁻¹ | C19H17FN6O | 5 MG

Supplier:  Medchemexpress LLC HY1319695MG

ASK1-IN-2 is a small-molecule, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 32.8 nM. It is supplied as a white to off-white solid and is available in multiple package sizes and as DMSO solutions for research use; preclinical studies report activity in dextran sulfate sodium (DSS)-induced ulcerative colitis models.

• Potent ASK1 inhibition (IC50 32.8 nM).
• Orally active compound demonstrated in preclinical models.
• Shown to improve DSS-induced ulcerative colitis in mice.
• Blocks ASK1-p38/JNK signaling and reduces inflammatory cytokines.
• High purity (99.6%) and solid, white to off-white physical form.
• Available as solid, solid + solvent, and solution formats for flexible use.
• Powder storage: -20°C for long-term stability; solvent storage guidelines provided.

Catalog No. 50-002-62640