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Cayman Chemical ASK1 InhIbItr 10 5mg
Supplier: Cayman Chemical 285125 MG
An orally bioavailable inhibitor of ASK1 (IC50 = 14 nM); selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF (IC50s = >10,000 nM for all); inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner
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