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Medchemexpress LLC ASN007 benzenesulfonate (ERK-IN-3 benzenesulfonate) | 2055597-39-0 | 99.7% | 632.11 | 100 MG
SDP

Catalog No. 5000348188
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ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of ERK. It demonstrates potent inhibition of ERK1/2 with low single-digit nanomolar IC50 values. This compound exhibits significant antiproliferative activity against various tumor cells and is suitable for research into cancers driven by RAS mutations.

  • Potent and orally active ERK inhibitor
  • Inhibits ERK1/2 with low single-digit nM IC50 values
  • Exhibits significant antiproliferative activity against various tumor cells
  • Useful for research of cancers driven by RAS mutations
  • Inhibits the phosphorylation of ERK1/2 substrates (e.g., RSK1, FRA1, Elk1) in various cell lines
  • Induces G0/G1 phase cell cycle arrest in various cells
  • Significantly inhibits tumor growth and shows good tolerance in nude mice bearing BRAF and KRAS mutant xenograft tumors

Catalog No. 50-003-48188 Supplier Medchemexpress LLC Supplier No. HY136579A100MG
May include imposed supplier surcharges.
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ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of ERK. It demonstrates potent inhibition of ERK1/2 with low single-digit nanomolar IC50 values. This compound exhibits significant antiproliferative activity against various tumor cells and is suitable for research into cancers driven by RAS mutations.

  • Potent and orally active ERK inhibitor
  • Inhibits ERK1/2 with low single-digit nM IC50 values
  • Exhibits significant antiproliferative activity against various tumor cells
  • Useful for research of cancers driven by RAS mutations
  • Inhibits the phosphorylation of ERK1/2 substrates (e.g., RSK1, FRA1, Elk1) in various cell lines
  • Induces G0/G1 phase cell cycle arrest in various cells
  • Significantly inhibits tumor growth and shows good tolerance in nude mice bearing BRAF and KRAS mutant xenograft tumors

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