Medchemexpress LLC ASN007 benzenesulfonate (ERK-IN-3 benzenesulfonate) | 2055597-39-0 | 99.7% | 632.11 | 100 MG

Supplier:  Medchemexpress LLC HY136579A100MG

ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of ERK. It demonstrates potent inhibition of ERK1/2 with low single-digit nanomolar IC50 values. This compound exhibits significant antiproliferative activity against various tumor cells and is suitable for research into cancers driven by RAS mutations.

• Potent and orally active ERK inhibitor
• Inhibits ERK1/2 with low single-digit nM IC50 values
• Exhibits significant antiproliferative activity against various tumor cells
• Useful for research of cancers driven by RAS mutations
• Inhibits the phosphorylation of ERK1/2 substrates (e.g., RSK1, FRA1, Elk1) in various cell lines
• Induces G0/G1 phase cell cycle arrest in various cells
• Significantly inhibits tumor growth and shows good tolerance in nude mice bearing BRAF and KRAS mutant xenograft tumors

Catalog No. 50-003-48188