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AdipoGen Asprosin human ELISA Kit
Supplier: AdipoGen AG45B0010KI01
Colorimetric Sandwich ELISA Assay. Detects human asprosin. Assay Type Sandwich. Detection Type Colorimetric. Sample Type Cell Culture Supernatant, Plasma, Serum. Range 0.3125 to 20ng/ml. Sensitivity 230pg/ml. Asprosin is a new fasting-induced protein hormone that targets the liver to increase plasma glucose levels. Asprosin is the C-terminal cleavage product of the protein Fibrillin-1. Asprosin is secreted from white adipose tissue and increases hepatic glucose production by using cAMP as a second messenger, leading to activation of protein Kinase A. Reduction of asprosin levels protects against metabolic syndrome-associated hyperinsulinism. Asprosin may act as a circulating hunger signal. Indeed, peripherally injected recombinant asprosin can cross the blood-brain barrier and intracerebroventricular i.c.v. injection of recombinant asprosin stimulated appetite in wild-type mice, indicating a central mechanism of action.
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