AdipoGen Asprosin human rec His

Supplier:  AdipoGen AG40B0174C010

Recombinant protein. Human asprosin aa 2732-2871 is fused at the C-terminus to a His-tag. Source E. coli. Lyophilized from 0.2µm-filtered solution in 50mM Tris-HClpH 8.2, 200mM NaCl. Asprosin is a new fasting-induced protein hormone that targets the liver to increase plasma glucose levels. Asprosin is the C-terminal cleavage product of the protein pro-Fibrillin-1. Asprosin is secreted from white adipose tissue and increases hepatic glucose production by using cAMP as a second messenger, leading to activation of protein Kinase A. Reduction of Asprosin levels protects against metabolic syndrome-associated hyperinsulinism. Asprosin may act as a circulating hunger signal. Indeed, peripherally injected recombinant asprosin can cross the blood-brain barrier and intracerebroventricular i.c.v. injection of recombinant asprosin stimulated appetite in wild-type mice, indicating a central mechanism of action.

Catalog No. 50-256-2906