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Cayman Chemical AST-1306tosylate 10mg
Supplier: Cayman Chemical 2970810 MG
An irreversible EGFR, HER2, and HER4 inhibitor (IC50s = 0.5, 3, and 0.8 nM, respectively); selective for EGFR, HER2, and HER4 over a panel of 23 additional kinases (IC50s = >10 µM); inhibits EGFRT790M/L858R (IC50 = 12 nM in a cell-free assay); decreases EGFR, ERK1/2, and Akt phosphorylation in Calu-3, A549, and SKOV3 cancer cells from 0.001-1 µM; inhibits proliferation of various cancer cells (IC50s = 0.23-16 µM); reduces tumor growth in Calu-3, A549, SKOV3, and HO8910 mouse xenograft models at 25, 50, and 100 mg/kg per day
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