Medchemexpress LLC AST 487 | 630124-46-8 | 98.9% | 529.56 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY15002

AST 487 is a potent RET kinase inhibitor with an IC50 of 880 nM, and also demonstrates inhibitory activity against Flt-3 with an IC50 of 520 nM. It effectively inhibits RET autophosphorylation and the activation of downstream effectors, making it suitable for studies on human thyroid cancer cell lines with activating RET mutations.

• Inhibits RET kinase (IC50 880 nM)
• Inhibits Flt-3 (IC50 520 nM)
• Targets other kinases including KDR, Flt-4, c-Kit, and c-Abl
• Potently inhibits growth of human thyroid cancer cell lines with activating RET mutations
• Functions as a novel, mutant FLT3 inhibitor
• Inhibits cellular proliferation in FLT3-ITD-Ba/F3 and D835Y-Ba/F3 cells (IC50 less than 5 nM)

Catalog No. 50-003-60996