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Cayman Chemical AstragalosIde II 50mg
Supplier: Cayman Chemical 4013950 MG
A triterpene saponin with diverse biological activities; increases the phosphatase activity of CD45 in cell-free assays using pNPP or OMFP as substrates (EC50s = 9.23 and 5.37 UG/ml, respectively); inhibits replication of dengue virus serotypes 1 and 3 in infected Vero cells (MIC = 1.56 UG/ml for both); increases concanavalin A-induced proliferation of primary mouse splenocytes at 30 nM; inhibits autophagy and enhances apoptosis induced by cisplatin in SGC-7901 gastric cancer cells at 50 µM; prevents decreases in small intestine and colon length, as well as body weight, in a mouse model of TNBS-induced colitis at 10 mg/kg; decreases the urinary albumin-to-creatinine ratio and improves histopathological scores in a rat model of STZ-induced diabetic nephropathy at 3.2 and 6.4 mg/kg
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