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Medchemexpress LLC Astressin 2B TFA | 99.54% | 4041.69 | 500 UG
Supplier: Medchemexpress LLC HYP1108A500UG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. It also reverses the protective effects of Urocortin 1 and attenuates stress-induced anxiety-related behaviors. This product is a valuable tool for investigating the intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist (IC50=0.57 nM).
- Blood-brain barrier-impermeable.
- Exacerbates indomethacin-induced hemorrhagic intestinal injury.
- Reverses protective effects of urocortin 1.
- Attenuates stress-induced anxiety-related behaviors.
- Valuable tool for studying CRFR2 intestinal protective mechanisms.
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