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Apexbio Technology LLC AT-101 90141-22-3 50mg
SDP

Supplier:  Apexbio Technology LLC A319650

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AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers

Catalog No. 50-000-63183


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