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  6. Tocris Bioscience™ AT 101 Inhibitor

Tocris Bioscience™ AT 101 Inhibitor
SDP

Catalog No. NB336750MG Shop All R&D Systems Products
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NB336750MG 50 mg
NB336710MG 10 mg
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Catalog No. NB336750MG Supplier Tocris Bioscience™ Supplier No. NB336750MG

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Description

Low molecular weight, organic compound that may help regulate biological process.

Biological Activity:
R-(-)-enantiomer of gossypol. Mimics BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Storage: Store the unopened product at 2° to 8°C. Do not use past expiration date.

Specifications

Formulation C30H30O8
For Use With (Application) Inhibits apoptosis
Quantity 50 mg
Product Type Inhibitors
Molecular Weight (g/mol) 518.56g/mol
Solubility Soluble to 100mM in DMSO, 100mM in ethanol
Content And Storage -20°C
Target AT 101
Color Dark Purple

For Laboratory Research Use Only

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