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Medchemexpress LLC AT-533 | 908112-37-8 | 98.38% | 410.51 | 5 MG
Supplier: Medchemexpress LLC HY1488775MG
AT-533 is a potent Hsp90 and HSV inhibitor. It suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. Additionally, AT-533 inhibits the activation of downstream pathways such as Akt/mTOR/p70S6K, Erk1/2, and FAK.
- Inhibits tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).
- Decreases TNF-α, IL-1β, and IL-6 production in RAW264.7 and BV2 cells induced by HSV-1.
- Shows anti-angiogenic ability in a chorioallantoic membrane (CAM) model.
- Suppresses the expression of HIF-1α/VEGF signaling pathway-related proteins in MDA-MB-231 breast cancer xenografts in mice.
- Subacute toxicity tests showed no mortality, loss of appetite, body weight changes, or adverse reactions in Sprague-Dawley rats.
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