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Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 98.6% | C16H18Cl3N5O2 | 25 MG
Supplier: Medchemexpress LLC 25MGHY50943
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively. It is for research use only.
- Potent inhibitor of CDKs.
- Induces dose-dependent cytotoxicity and apoptosis in multiple myeloma cells.
- Inhibits cell cycle progression and induces apoptosis in human tumor cell lines.
- Inhibits transcription and RNA polymerase II in leukemia cell lines.
- Inhibits tumor growth in human xenograft mouse models.
- Investigated in clinical trials for various cancers.
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