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Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 99.2% | C16H18Cl3N5O2 | 1 ML
Supplier: Medchemexpress LLC HY5094310MM/1ML
AT7519 Hydrochloride is a potent inhibitor of cyclin-dependent kinases (CDKs), with low nanomolar IC50s for CDK1, CDK2, CDK4-CDK6, and CDK9. It induces cytotoxicity and apoptosis in multiple myeloma (MM) cells, linked to GSK-3β activation and inhibition of RNA polymerase II. The compound inhibits tumor growth in MM xenograft mouse models and has been involved in clinical trials for various cancers.
- Potent inhibitor of CDKs (CDK1, CDK2, CDK4-CDK6, CDK9)
- Induces cytotoxicity and apoptosis in MM cells
- Overcomes cytokine and BMSC protective effects
- Inhibits RNA polymerase II CTD phosphorylation and RNA synthesis
- Inhibits cell cycle progression and reduces antiapoptotic protein levels
- Inhibits tumor growth in MM xenograft mouse models
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