Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 99.2% | C16H18Cl3N5O2 | 100 MG

Supplier:  Medchemexpress LLC HY50943100MG

AT7519 Hydrochloride is a potent inhibitor of Cyclin-Dependent Kinases (CDKs), exhibiting strong inhibitory activity against CDK1, CDK2, CDK4 to CDK6, and CDK9. It induces dose-dependent cytotoxicity and apoptosis in MM cells and inhibits cell cycle progression in various human tumor cell lines. In preclinical studies, AT7519 Hydrochloride effectively inhibits tumor growth in both human MM and HCT116 xenograft mouse models.

• Potent inhibitor of CDKs (IC50 values range from <10 nM to 210 nM)
• Induces cytotoxicity and apoptosis in MM cells
• Overcomes cytokine and BMSC protective effects
• Inhibits RNA polymerase II CTD phosphorylation and RNA synthesis
• Inhibits cell cycle progression and induces apoptosis in tumor cell lines
• Reduces antiapoptotic protein levels
• Inhibits tumor growth in MM and HCT116 xenograft models

Catalog No. 50-003-58835