Apexbio Technology LLC AT7867 857531-00-1 5mg

Supplier:  Apexbio Technology LLC A56535

AT7867 (CAS 857531-00-1) is a small molecule ATP-competitive inhibitor that targets Akt1 Akt2 Akt3 p70S6 kinase (p70S6K) and protein kinase A (PKA) with reported IC50 values of 32 nM 17 nM 47 nM 85 nM and 20 nM respectively Akt or protein kinase B is a serine/threonine kinase involved in cellular pathways such as glucose metabolism apoptosis proliferation transcription and migration AT7867 suppresses proliferation across various human tumor cell lines including MES-SA MDA-MB-468 MCF-7 HCT116 and HT29 with IC50 values ranging from 0 9 to 3 M Additionally it inhibits GSK3 within these lines (IC50 2 4 M) and induces apoptosis in U87MG glioblastoma cells via dose- and time-dependent Akt pathway inhibition In PTEN-deficient tumor xenograft models AT7867 reduces phosphorylation of Akt/p70S6K substrates and impedes tumor growth supporting its use in cancer research

Catalog No. 50-224-0147