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Medchemexpress LLC ATH686 | 853299-52-2 | 99.54% | 515.53 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY150035MG

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ATH686 is a potent, selective, and ATP-competitive FLT3 inhibitor that targets mutant FLT3 protein kinase activity. It inhibits the proliferation of cells harboring FLT3 mutants by inducing apoptosis and cell cycle inhibition, also exhibiting antileukemic effects.

  • Potently inhibits cell proliferation (IC50 around 0.001 μM) in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells
  • Induces apoptosis
  • Inhibits autophosphorylation of mutant FLT3
  • Exhibits antileukemic effects

Catalog No. 50-003-61273


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