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Medchemexpress LLC ATIC-IN-1 acetate | 3067165-96-9 | C23H37N7O7 | 1 ML
Supplier: Medchemexpress LLC HY150252A10MM/1ML
ATIC-IN-1 acetate, also referred to as compound 14, is a specific inhibitor targeting the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). This dimerization is critical for the AICAR transformylase activity of ATIC, an enzyme involved in de novo purine biosynthesis. It demonstrates anti-tumor activity by reducing cell numbers and cell division rates.
- Inhibits ATIC dimerization crucial for AICAR transformylase activity
- Ki value of 685 nM
- Exhibits anti-tumor activity by reducing cell numbers
- Reduces cell division rates
- Specific inhibitor at 10 μM and 50 μM
- Inhibits proliferation of MCF-7 cells at 100-500 μM over 48 hours
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