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Medchemexpress LLC Atic-in-1 acetate | 3067165-96-9 | C23H37N7O7 | 100 MG
Supplier: Medchemexpress LLC HY150252A100MG
ATIC-IN-1 acetate (compound 14) is an inhibitor targeting Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. This enzyme catalyzes de novo purine biosynthesis, and ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity by reducing cell numbers and cell division rates.
- Acts as a specific inhibitor and shows non-specific aggregate mechanism in the presence of 1 mg/mL and 10 mg/mL BSA.
- Inhibits the proliferation of MCF-7 cells.
- Leads to a reduction in cell division rather than an increase in cell death.
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