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Medchemexpress LLC ATIC-IN-1 acetate | 3067165-96-9 | C23H37N7O7 | 25 MG
Supplier: Medchemexpress LLC 25MGHY150252A
ATIC-IN-1 acetate, also known as compound 14, is an inhibitor that targets the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). This dimerization is crucial for the AICAR transformylase activity of ATIC, which plays a role in de novo purine biosynthesis. It demonstrates anti-tumor activity by reducing cell numbers and cell division rates.
- Inhibits ATIC dimerization with a Ki value of 685 nM
- Exhibits anti-tumor activity
- Reduces cell numbers and cell division rates
- Can be used in research to study ATIC dimerization and its role in purine biosynthesis and tumor proliferation
- Inhibits the proliferation of MCF-7 cells at concentrations of 100-500 μM over 48 hours
- At 250 μM for 24-72 hours, it reduces cell division rather than increasing cell death
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