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Medchemexpress LLC ATIC-IN-1 acetate | 3067165-96-9 | C23H37N7O7 | 5 MG
Supplier: Medchemexpress LLC HY150252A5MG
ATIC-IN-1 acetate is an inhibitor targeting Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization, with a Ki value of 685 nM. This compound catalyzes de novo purine biosynthesis, and ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. It exhibits anti-tumor activity by reducing cell numbers and cell division rates.
- Targets ATIC dimerization.
- Exhibits anti-tumor activity via reduction in cell numbers and cell division rates.
- Shows nonspecific aggregate mechanism in the presence of 1 mg/mL and 10 mg/mL BSA.
- Inhibits the proliferation of MCF-7 cells (100-500 μM; 48 h).
- Reduces cell division rather than increasing cell death (250 μM; 24-72 h).
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