Cayman Chemical AtIpamezolehydrochlorIde 50mg

Supplier:  Cayman Chemical 900118150 MG

A histamine H4 receptor antagonist (Ki 12.5 nM for the human receptor) selective for the histamine H4 receptor over histamine H1 H2 and H3 receptors (Kis >1000 >1000 and 1043 nM respectively for the human receptors) as well as 48 other receptors ion channels and transporters at 1 UM and 66 kinases at 10 UM inhibits histamine-induced chemotaxis of isolated mouse bone marrow-derived mast cells (IC50 8 nM) reduces ovalbumin-induced BALF eosinophil infiltration in an ovalbumin-sensitized mouse model of asthma from 0.2-20 mg/kg decreases ear edema in a mouse model of FITC-induced contact hypersensitivity and inhibits histamine-induced pruritis in mice at 20 mg/kg reduces nephropathy but does not affect body weight or blood glucose levels in a mouse model of STZ-induced diabetes at 100 mg/kg

Catalog No. 50-289-5040