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Cayman Chemical ATN161trIfluoroACTAte sal 10mg
Supplier: Cayman Chemical 3405610 MG
An integrin receptor antagonist; binds to αVβ3 and αVβ5 receptors (Kds = 0.69 and 1 µM, respectively) in MDA-MB-231 cells; inhibits the interaction between αVβ5 and human ACE2 or SARS-CoV-2 spike protein in cell-free assays; reduces viral titers in Vero E6 cells infected with SARS-CoV-2 (EC50 = 3.16 µM); inhibits VEGF-induced migration and capillary tube formation of primary human choroidal endothelial cells at 0.1 µM; reduces tumor growth and metastasis in an MDA-MB-231 mouse xenograft model at 1 mg/kg; reduces infarct volume and edema in a mouse model of MCAO-induced ischemic stroke at 1 mg/kg
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