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Apexbio Technology LLC Atomoxetine HCl 82248-59-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B22445.1
Atomoxetine HCl (CAS 82248-59-7) is a selective inhibitor of the norepinephrine transporter (NET) a membrane protein responsible for norepinephrine reuptake and synaptic homeostasis Atomoxetine shows high selectivity towards human NET (Ki 5 nM) with substantially lower affinity for serotonin (Ki 77 nM) and dopamine transporters (Ki 1451 nM) In preclinical studies using rat models atomoxetine elevated extracellular norepinephrine and dopamine specifically in the prefrontal cortex region without affecting dopamine levels in the striatum or nucleus accumbens These traits render it useful in research on neurotransmitter regulation related to cognition and attention disorders
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