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Medchemexpress LLC Atopaxar | 751475-53-3 | 99.9% | 527.63 | 5 MG
Supplier: Medchemexpress LLC HY182005MG
Atopaxar is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. As an antiplatelet agent, it interferes with platelet signaling and can be used for the research of atherothrombotic disease.
- Potent, orally active, selective and reversible PAR-1 antagonist
- Interferes with platelet signaling
- Used for research of atherothrombotic disease
- Inhibits human platelet aggregation induced by thrombin or TRAP
- Does not inhibit PRP aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to 20 μM
- Causes dose-dependent prolongation of time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model
- Does not prolong bleeding time in guinea pigs at high dosages
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