Apexbio Technology LLC Atorvastatin Calcium 134523-03-8 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A43675.1

Atorvastatin Calcium (CAS 134523-03-8) is a selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme involved in cholesterol biosynthesis By targeting this enzyme atorvastatin reduces intracellular cholesterol production thereby stimulating hepatic expression of low-density lipoprotein (LDL) receptors and facilitating plasma LDL clearance Atorvastatin exhibits an IC50 of approximately 154 nM against HMG-CoA reductase Clinically atorvastatin decreases total cholesterol and LDL levels applicable to research models of hypercholesterolemia and cardiovascular disease including studies on lipid metabolism and atherosclerosis pathogenesis

Catalog No. 50-000-61608