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Apexbio Technology LLC Atorvastatin Calcium 134523-03-8 50mg
Supplier: Apexbio Technology LLC A436750
Atorvastatin Calcium (CAS 134523-03-8) is a selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme involved in cholesterol biosynthesis By targeting this enzyme atorvastatin reduces intracellular cholesterol production thereby stimulating hepatic expression of low-density lipoprotein (LDL) receptors and facilitating plasma LDL clearance Atorvastatin exhibits an IC50 of approximately 154 nM against HMG-CoA reductase Clinically atorvastatin decreases total cholesterol and LDL levels applicable to research models of hypercholesterolemia and cardiovascular disease including studies on lipid metabolism and atherosclerosis pathogenesis
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