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Medchemexpress LLC ATP-polyamine-biotin | 1800401-93-7 | 98.06% | 50 MG
Supplier: Medchemexpress LLC HYD018350MG
ATP-polyamine-biotin is the first cell-permeable ATP analogue, designed to function as an efficient kinase cosubstrate. It facilitates the biotin labeling of kinase substrates directly within live cells. This innovative compound allows for in vitro biotinylation experiments where the presence of the kinase, ATP-polyamine-biotin, and substrate leads to successful labeling, which is inhibited by kinase inhibitors or cleavage of the phosphoramidate bond.
- Promotes biotin labeling of kinase substrates in live cells.
- Functions as an efficient kinase cosubstrate.
- Observes biotinylation only in the presence of kinase.
- Inhibited by kinase inhibitors like staurosporine.
- Sensitive to acid incubation due to phosphoramidate bond cleavage.
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