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Medchemexpress LLC Atrasentan | 173937-91-2 | C29H38N2O6 | 1 ML
Supplier: Medchemexpress LLC HY1540310MM/1ML
Atrasentan is an endothelin receptor antagonist known for its potent activity against the ETA receptor, with an IC50 of 0.0551 nM. Also identified as ABT-627, it plays a role in the GPCR/G Protein pathway and has a molecular formula of C29H38N2O6 and a molecular weight of 510.62. This compound is utilized in research studying various biological activities.
- Significantly inhibits LNCaP and C4-2b prostate cancer cell growth
- Enhances down-regulation of NF-κB DNA binding activity when combined with Taxotere
- Induces several CYPs and drug transporters, such as CYP3A4
- Functions as a moderate P-gp inhibitor and a weak BCRP inhibitor
- Inhibits pressor response induced by big endothelin-1 in pithed rats
- Inhibits C4-2b tumor growth within the bone environment in the SCID-hu model
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