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Medchemexpress LLC Atrasentan hydrochloride | 195733-43-8 | C29H39ClN2O6 | 1 ML
Supplier: Medchemexpress LLC HY15403A10MM/1ML
Atrasentan hydrochloride is a selective endothelin A receptor antagonist, primarily used for research purposes. It has demonstrated significant inhibition of LNCaP and C4-2b prostate cancer cell growth in vitro, with an IC50 of 0.0551 nM for ETA. This compound also impacts drug metabolism by inducing several CYPs and drug transporters.
- Selectively antagonizes endothelin A receptors
- Inhibits LNCaP and C4-2b prostate cancer cell growth
- Induces CYPs and drug transporters
- Acts as a moderate P-gp inhibitor and weak BCRP inhibitor
- Demonstrates in vivo inhibition of pressor response induced by big endothelin-1
- Inhibits C4-2b tumor growth in SCID-hu model
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