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Medchemexpress LLC Atrasentan hydrochloride | 195733-43-8 | C29H39ClN2O6 | 100 MG
Supplier: Medchemexpress LLC HY15403A100MG
Atrasentan hydrochloride is a selective endothelin A receptor antagonist, exhibiting an IC50 of 0.0551 nM for ETA. It is designated for research purposes only and is not intended for patient use. This compound presents as an off-white to gray solid with a molecular weight of 547.08.
- Effectively inhibits the growth of LNCaP and C4-2b prostate cancer cells.
- Significantly induces several CYPs and drug transporters.
- Acts as a moderate P-gp inhibitor and a weak BCRP inhibitor.
- Suppresses pressor response initiated by big endothelin-1 in pithed rats.
- Partially inhibits C4-2b tumor progression within the bone environment in the SCID-hu model.
- Soluble in DMSO and water with specific preparation requirements.
- Recommended storage at 4°C in sealed conditions, away from moisture.
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