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Medchemexpress LLC ATX-II (TFA) | 99.65% | 4934.62 (free acid) | 100 UG
Supplier: Medchemexpress LLC HYP1604A100UG
ATX-II TFA is a selective sodium channel modulator toxin that enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. This compound exhibits a pro-arrhythmic effect by slowing intrinsic heart rate, prolonging the QT interval and sinus node recovery time, and inducing sinus pauses and arrests. It is suitable for research related to atrial fibrillation, long QT syndrome, and long QT3 syndrome.
- Enhances tetrodotoxin sensitive resurgent and persistent sodium currents in large diameter mouse DRG neurons.
- Shifts the voltage dependence of activation and steady-state fast inactivation of TTXS sodium channels to more hyperpolarized potentials.
- Increases diastolic tension and arrhythmia score in isolated rat right atrial tissue.
- Significantly increases diastolic intracellular Ca2+ concentrations in isolated rat atrial myocytes.
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