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Apexbio Technology LLC Aurora A Inhibitor I 1158838-45-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A41265.1
Aurora A Inhibitor I (CAS 1158838-45-9) is a selective and potent small-molecule inhibitor of Aurora A kinase exhibiting an IC50 of 3 4 nM Aurora kinases are serine/threonine kinases crucially involved in mitotic progression with Aurora A specifically implicated in centrosome maturation and spindle assembly Aurora A Inhibitor I exerts high specificity significantly favoring Aurora A over Aurora B or cyclin-dependent kinases (CDKs) in vitro Subtle amino acid changes within kinase active sites significantly impact inhibitor potency highlighting residue-dependent selectivity This compound represents a valuable research tool for investigating Aurora A-related signaling pathways and their roles in cell division and oncogenesis
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