Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.9% | 603.60 | 100 MG

Supplier:  Medchemexpress LLC HY19816A100MG

Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects.

• Third-generation, irreversible and orally active selective EGFR inhibitor.
• Potent inhibition of EGFR L858R (IC50: 0.18 nM), EGFR T790M (IC50: 0.18 nM), and wild-type EGFR (IC50: 7.68 nM).
• BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma.
• Exhibits anticancer effects.
• Selectively inhibits mutant EGFR phosphorylation.
• Inhibits phosphorylation of downstream targets Akt and ERK1/2 in NCI-H1975 and HCC827 cells.
• Inhibits EGFR-mutant tumor growth in xenograft models over extended duration.

Catalog No. 50-004-00849