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Medchemexpress LLC Avj16 | 2775241-92-2 | 99.6% | 469.53 | C28H27N3O4 | 5 MG
SDP

Catalog No. 5000221424
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AVJ16 is a small-molecule inhibitor of the insulin-like growth factor 2 mRNA binding protein IGF2BP1. It binds IGF2BP1 (reported Kd ≈ 1.4 μM) and has demonstrated inhibition of cancer cell migration, proliferation, colony and spheroid formation, and induction of apoptosis in preclinical in vitro and xenograft studies.

  • Targets IGF2BP1 RNA-binding activity (reported Kd 1.4 μM).
  • Inhibits proliferation, invasion, and migration of IGF2BP1-expressing cancer cells.
  • Suppresses colony formation and spheroid growth in relevant cell lines.
  • Induces apoptosis in susceptible cell lines in vitro.
  • Demonstrates antitumor activity in xenograft models at reported dosing.
  • Available as solid and as a 10 mM solution in DMSO for convenient use.

Catalog No. 50-002-21424 Supplier Medchemexpress LLC Supplier No. HY1448735MG
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AVJ16 is a small-molecule inhibitor of the insulin-like growth factor 2 mRNA binding protein IGF2BP1. It binds IGF2BP1 (reported Kd ≈ 1.4 μM) and has demonstrated inhibition of cancer cell migration, proliferation, colony and spheroid formation, and induction of apoptosis in preclinical in vitro and xenograft studies.

  • Targets IGF2BP1 RNA-binding activity (reported Kd 1.4 μM).
  • Inhibits proliferation, invasion, and migration of IGF2BP1-expressing cancer cells.
  • Suppresses colony formation and spheroid growth in relevant cell lines.
  • Induces apoptosis in susceptible cell lines in vitro.
  • Demonstrates antitumor activity in xenograft models at reported dosing.
  • Available as solid and as a 10 mM solution in DMSO for convenient use.

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