Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 100 MG

Supplier:  Medchemexpress LLC HY144873100MG

AVJ16 is a cancer cell migration inhibitor targeting the insulin-like growth factor 2 mRNA binding protein IGF2BP1 with an affinity (Kd) of 1.4 μM. It interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation, inhibiting proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells. It also suppresses colony formation and spheroid growth, induces apoptosis in certain cell lines, and demonstrates antitumor activity in xenograft mouse models.

• Targets IGF2BP1, a key protein in cancer cell migration.
• Interferes with mRNA binding to regulate gene expression.
• Inhibits proliferation, invasion, and migration of lung adenocarcinoma cells.
• Suppresses colony formation and spheroid growth.
• Induces apoptosis in relevant cell lines.
• Shows antitumor activity in xenograft mouse models.

Catalog No. 50-003-55516