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Apexbio Technology LLC AXL1717 477-47-4 250mg
Supplier: Apexbio Technology LLC A3209250
AXL1717 (CAS 477-47-4) also known as picropodophyllin is a selective inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase exhibiting an IC50 of 0 24 0 33 M IGF-1R a transmembrane receptor activated by IGF-1 is implicated in cellular proliferation and survival and its overexpression is associated with various malignancies AXL1717 demonstrates dose-dependent inhibition of cell viability induces G2-M cell cycle arrest and promotes apoptosis in multiple myeloma and colon cancer cell lines In murine xenograft models combination with HDAC inhibitor LBH589 prolongs survival AXL1717 has progressed to phase I/II trials in non-small cell lung cancer
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