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Apexbio Technology LLC AY 9944 dihydrochloride(Synonyms: AY-9944, AY9944, AY 9944, trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride), 10mg, CAS: 366-93-8.
Supplier: Apexbio Technology LLC A865810
AY 9944 dihydrochloride (CAS 366-93-8) is a selective inhibitor of 7-sterol reductase (Dhcr7) an enzyme involved in cholesterol biosynthesis through NADPH-dependent conversion of 7-dehydrocholesterol to cholesterol AY 9944 dihydrochloride inhibits recombinant human 7-sterol reductase expressed in yeast cells with an IC50 of 13 nM In an SD rat model of Smith-Lemli-Opitz syndrome AY 9944 treatment leads to increased accumulation of 7-dehydrocholesterol and decreased cholesterol levels across various tissues Additionally in PBMCs isolated from AIDS patients AY 9944 intervention restored mitogenic responses and cytokine production suggesting research applications in immunological studies and cholesterol metabolism disorders
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