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Apexbio Technology LLC AZ 10606120 dihydrochloride 607378-18-7 50mg
Supplier: Apexbio Technology LLC B541050
AZ 10606120 dihydrochloride (CAS 607378-18-7) is a potent antagonist of the P2X7 receptor an ATP-gated ion channel implicated in mediating a variety of cellular responses It exhibits high binding affinity for human and rat P2X7 receptors with Kd values of 1 4 nM and 1 9 nM respectively In vitro studies demonstrate that AZ 10606120 binds reversibly and saturably to the P2X7 receptor with ligand modulation indicating both positive and negative cooperativity In vivo intratumoral injection of AZ 10606120 in murine models significantly suppressed tumor growth and reduced angiogenesis This compound is utilized as a molecular tool to investigate P2X7 receptor function in cellular signaling and tumor biology and remains in preclinical development
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