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Medchemexpress LLC AZ 11645373 | 227088-94-0 | 99.5% | 463.51 | 10 MG
SDP

Catalog No. 5000344707
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AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors. It inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells, with an IC50 value of 90 nM.

  • Highly selective and potent antagonist at human (but not rat) P2X7 receptors
  • Inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells with an IC50 value of 90 nM
  • Produces a concentration-dependent inhibition of BzATP-mediated calcium transients
  • Has no significant effect on basal levels of IL-1β in culture medium of LPS-treated cells, but produces a concentration-dependent inhibition of ATP-mediated IL-1β release

Catalog No. 50-003-44707 Supplier Medchemexpress LLC Supplier No. HY10867010MM/1ML
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AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors. It inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells, with an IC50 value of 90 nM.

  • Highly selective and potent antagonist at human (but not rat) P2X7 receptors
  • Inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells with an IC50 value of 90 nM
  • Produces a concentration-dependent inhibition of BzATP-mediated calcium transients
  • Has no significant effect on basal levels of IL-1β in culture medium of LPS-treated cells, but produces a concentration-dependent inhibition of ATP-mediated IL-1β release

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